Translational Research Studies

In 2018 ESCAT, a novel tool designed to enhance and standardize precision oncology, developed on the initiative of the ESMO Translational Research and Precision Medicine Working Group, has been presented. ESCAT employs data from massive sequencing (as next-generation sequencing analysis, NGS) to establish a hierarchy of genetic alterations in a tumor, thereby indicating those alterations that should be the primary focus of therapeutic action.

Organoids are three-dimensional cell cultures generated by multipotent adult stem cells or pluripotent (embryonic or induced in vitro) stem cells in the presence of an extracellular matrix that self-organize in tissue-like structures that partially reproduce features and function of the tissue of origin.

Brain tumours are among the cancers with the worst outlook and are hard to treat owing to factors such as inoperable locations in the brain and the difficulty of developing drugs that can cross the blood-brain barrier.